If the outermost circle in the shown figure indicates manipulative zone of biosphere reserve then 1& 2 represent:
Biosphere reserves are divided into a number of zone. The outer most circle of biosphere represent manipulative zone followed by buffer zone and core zone respectively from outside to inside.

When a person suffers from chest pain :
i. the reason for this suffering is decreased blood flow and simultaneously lowered oxygen supply to an area of the heart.
ii. deprived of oxygen, myocardium opts for alternative pathways i.e. anaerobic respiration and its byproduct ethanol causes the pain.